TED,Trends

Tumeurs cerebrales : un traitement combine pourrait changer la donne		03/10/2025
«A 81 ans, Yehezkel Ben-Ari continue de bousculer les certitudes médicales. Neurobiologiste de renom, fondateur de l'Institut de neurobiologie de la Méditerranée à Marseille, il s'est imposé par ses découvertes sur l'épilepsie et le développement du cerveau. Mais sa retraite académique ne l'a pas arrêté : il a choisi de se lancer dans l'entrepreneuriat scientifique.Aujourd'hui, à travers BA Oncomedical, filiale de Neurochlore, il propose une approche radicalement nouvelle contre les tumeurs cérébrales : un traitement combiné qui cible à la fois la tumeur et son environnement neuronal. Rencontre.» [...] « Quel est le potentiel de ces nouvelles molécules ? Il est immense. NKCC1, la cible que nous bloquons, est impliquée dans de nombreuses maladies : cancers bien sûr, mais aussi les troubles neurodéveloppementaux dont l’autisme, Alzheimer, Parkinson… Une molécule propriétaire efficace sur cette cible pourrait valoir très cher et ouvrir de multiples indications. Pour moi, c’est un champ d’avenir aussi important que le Combo. »...
<<	lefigaro

Polygenic and developmental profiles of autism differ by age at diagnosis | Nature		01/10/2025
«Abstract Although autism has historically been conceptualized as a condition that emerges in early childhood1,2, many autistic people are diagnosed later in life3,4,5. It is unknown whether earlier- and later-diagnosed autism have different developmental trajectories and genetic profiles. Using longitudinal data from four independent birth cohorts, we demonstrate that two different socioemotional and behavioural trajectories are associated with age at diagnosis. In independent cohorts of autistic individuals, common genetic variants account for approximately 11% of the variance in age at autism diagnosis, similar to the contribution of individual sociodemographic and clinical factors, which typically explain less than 15% of this variance. We further demonstrate that the polygenic architecture of autism can be broken down into two modestly genetically correlated (rg=0.38, s.e.=0.07) autism polygenic factors. One of these factors is associated with earlier autism diagnosis and lower social and communication abilities in early childhood, but is only moderately genetically correlated with attention deficit-hyperactivity disorder (ADHD) and mental-health conditions. Conversely, the second factor is associated with later autism diagnosis and increased socioemotional and behavioural difficulties in adolescence, and has moderate to high positive genetic correlations with ADHD and mental-health conditions. These findings indicate that earlier- and later-diagnosed autism have different developmental trajectories and genetic profiles. Our findings have important implications for how we conceptualize autism and provide a model to explain some of the diversity found in autism.»...
<<	nature