MyBotsBlog -7 days report
Chronologie Sun May 19 15:00:16 CEST 2024
19/05/24 L'Etat condamne pour des heures de cours non remplacees : « Ils nous ont contraints d'en arriver la » - Le Parisien [leparisien]
18/05/24 Enrichment of a subset of Neanderthal polymorphisms in autistic probands and siblings | Molecular Psychiatry [nature]
14/05/24 Fever Effect May Improve Autism Symptoms - Neuroscience News [neurosciencenews]

TED,Trends
L'Etat condamne pour des heures de cours non remplacees : « Ils nous ont contraints d'en arriver la » - Le Parisien [leparisien]
Enrichment of a subset of Neanderthal polymorphisms in autistic probands and siblings | Molecular Psychiatry [nature]
Fever Effect May Improve Autism Symptoms - Neuroscience News [neurosciencenews]

TED,Trends
L'Etat condamne pour des heures de cours non remplacees : « Ils nous ont contraints d'en arriver la » - Le Parisien 19/05/2024


«A la veille du Congrès national de la fédération des conseils de parents d'élèves (FCPE), le président de la section des Hauts-de-Seine revient sur la condamnation inédite de l'Etat par le tribunal administratif de Cergy-Pontoise pour «Â carence dans l'organisation du service public de l'enseignement ». Les familles de cinq collégiens de Villeneuve-la-Garenne devraient être indemnisées.»...

<< leparisien

Enrichment of a subset of Neanderthal polymorphisms in autistic probands and siblings | Molecular Psychiatry 18/05/2024

«AbstractHomo sapiens and Neanderthals underwent hybridization during the Middle/Upper Paleolithic age, culminating in retention of small amounts of Neanderthal-derived DNA in the modern human genome. In the current study, we address the potential roles Neanderthal single nucleotide polymorphisms (SNP) may be playing in autism susceptibility in samples of black non-Hispanic, white Hispanic, and white non-Hispanic people using data from the Simons Foundation Powering Autism Research (SPARK), Genotype-Tissue Expression (GTEx), and 1000 Genomes (1000G) databases. We have discovered that rare variants are significantly enriched in autistic probands compared to race-matched controls. In addition, we have identified 25 rare and common SNPs that are significantly enriched in autism on different ethnic backgrounds, some of which show significant clinical associations. We have also identified other SNPs that share more specific genotype-phenotype correlations but which are not necessarily enriched in autism and yet may nevertheless play roles in comorbid phenotype expression (e.g., intellectual disability, epilepsy, and language regression). These results strongly suggest Neanderthal-derived DNA is playing a significant role in autism susceptibility across major populations in the United States»...

<< nature

Fever Effect May Improve Autism Symptoms - Neuroscience News 14/05/2024


«Summary: Researchers are exploring how fever can temporarily improve autism symptoms. They aim to understand the cellular and molecular mechanisms behind this "fever effect" to develop therapies that mimic it.Their research focuses on the immune molecule IL-17a, which has shown promise in animal studies. By creating a biobank of samples from individuals with and without autism, the team hopes to translate these findings into effective treatments.» [...]
« Scientists are catching up to what parents and other caregivers have been reporting for many years: When some people with autism spectrum disorders experience an infection that sparks a fever, their autism-related symptoms seem to improve. With a pair of new grants from The Marcus Foundation, scientists at MIT and Harvard Medical School hope to explain how this happens in an effort to eventually develop therapies that mimic the “fever effect” to similarly improve symptoms. “Although it isn’t actually triggered by the fever, per se, the ‘fever effect’ is real, and it provides us with an opportunity to develop therapies to mitigate symptoms of autism spectrum disorders,” said neuroscientist Gloria Choi, associate professor in The Picower Institute for Learning and Memory and the Department of Brain and Cognitive Sciences at MIT. »...

<< neurosciencenews